Transmit design for MIMO wiretap channel with a malicious jammer

In this paper, we consider the transmit design for multi-input multi-output (MIMO) wiretap channel including a malicious jammer. We first transform the system model into the traditional three-node wiretap channel by whitening the interference at the legitimate user. Additionally, the eavesdropper channel state information (ECSI) may be fully or statistically known, even unknown to the transmitter. Hence, some strategies are proposed in terms of different levels of ECSI available to the transmitter in our paper. For the case of unknown ECSI, a target rate for the legitimate user is first specified. And then an inverse water-filling algorithm is put forward to find the optimal power allocation for each information symbol, with a stepwise search being used to adjust the spatial dimension allocated to artificial noise (AN) such that the target rate is achievable. As for the case of statistical ECSI, several simulated channels are randomly generated according to the distribution of ECSI. We show that the ergodic secrecy capacity can be approximated as the average secrecy capacity of these simulated channels. Through maximizing this average secrecy capacity, we can obtain a feasible power and spatial dimension allocation scheme by using one dimension search. Finally, numerical results reveal the effectiveness and computational efficiency of our algorithms.Comment: 2015 IEEE 81st Vehicular Technology Conference (VTC Spring

Behaviour Analysis of Left-Turning Mopeds at Signal Controlled Intersections – A Case Study in Yancheng City

Mopeds (electric bicycles and light motorcycles) are commonly used as a personal transportation mode in China. However, the understanding of characteristics of left-turning mopeds at signal-controlled intersections has been relatively limited. To bridge this gap, firstly, this paper proposed a video conversion method of moped movement data acquisition. Then, a method of data accuracy verification was introduced by comparing the results between the field experiment and the video conversion method. Secondly, the ideal traffic space for left-turn mopeds from different entrances was defined to analyse the characteristics of the left-turning mopeds at intersections. Further, three indicators, namely, transverse distance, the proportion of left-turning mopeds with crossing behaviour, and the average number of avoidance behaviour, were proposed and used to analyse the asymmetrical characteristics behaviour, crossing behaviour, and avoidance behaviour. Finally, based on empirical data collected from five signal-controlled intersections, the proposed methods and behaviours were analysed. This paper provides both a valid method of obtaining the position data of mopeds and a reliable basis for improving the safety of left-turning moped riders at urban signal-controlled intersections

Synergistic up-regulation of CXCL10 by virus and IFN γ in human airway epithelial cells.

Airway epithelial cells are the first line of defense against viral infections and are instrumental in coordinating the inflammatory response. In this study, we demonstrate the synergistic stimulation of CXCL10 mRNA and protein, a key chemokine responsible for the early immune response to viral infection, following treatment of airway epithelial cells with IFN γ and influenza virus. The synergism also occurred when the cells were treated with IFN γ and a viral replication mimicker (dsRNA) both in vitro and in vivo. Despite the requirement of type I interferon (IFNAR) signaling in dsRNA-induced CXCL10, the synergism was independent of the IFNAR pathway since it wasn't affected by the addition of a neutralizing IFNAR antibody or the complete lack of IFNAR expression. Furthermore, the same synergistic effect was also observed when a CXCL10 promoter reporter was examined. Although the responsive promoter region contains both ISRE and NFκB sites, western blot analysis indicated that the combined treatment of IFN γ and dsRNA significantly augmented NFκB but not STAT1 activation as compared to the single treatment. Therefore, we conclude that IFN γ and dsRNA act in concert to potentiate CXCL10 expression in airway epithelial cells via an NFκB-dependent but IFNAR-STAT independent pathway and it is at least partly regulated at the transcriptional level

ISAC-Enabled Beam Alignment for Terahertz Networks: Scheme Design and Coverage Analysis

As a key pillar technology for the future 6G networks, terahertz (THz) communication can provide high-capacity transmissions, but suffers from severe propagation loss and line-of-sight (LoS) blockage that limits the network coverage. Narrow beams are required to compensate for the loss, but they in turn bring in beam misalignment challenge that degrades the THz network performance. The high sensing accuracy of THz signals enables integrated sensing and communication (ISAC) technology to assist the LoS blockage and user mobility-induced beam misalignment, enhancing THz network coverage. In line with the 5G beam management, we propose a joint synchronization signal block (SSB) and reference signal (RS)-based sensing (JSRS) scheme to predict the need for beam switches, and thus prevent beam misalignment. We further design an optimal sensing signal pattern that minimizes beam misalignment with fixed sensing resources, which reveals design insights into the time-to-frequency allocation. We derive expressions for the coverage probability and spatial throughput, which provide instructions on the ISAC-THz network deployment and further enable evaluations for the sensing benefit in THz networks. Numerical results show that the JSRS scheme is effective and highly compatible with the 5G air interface. Averaged in tested urban use cases, JSRS achieves near-ideal performance and reduces around 80% of beam misalignment, and enhances the coverage probability by about 75%, compared to the network with 5G-required positioning ability

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly enriched in multiple tumor types and has emerged as a promising target for direct tumor-killing. Here, we demonstrate that NQO1-targeting prodrug β-lapachone triggers tumor-selective innate sensing leading to T cell-dependent tumor control. β-Lapachone is catalyzed and bioactivated by NQO1 to generate ROS in NQO1high tumor cells triggering oxidative stress and release of the damage signals for innate sensing. β-Lapachone-induced high mobility group box 1 (HMGB1) release activates the host TLR4/MyD88/type I interferon pathway and Batf3 dendritic cell-dependent cross-priming to bridge innate and adaptive immune responses against the tumor. Furthermore, targeting NQO1 is very potent to trigger innate sensing for T cell re-activation to overcome checkpoint blockade resistance in well-established tumors. Our study reveals that targeting NQO1 potently triggers innate sensing within TME that synergizes with immunotherapy to overcome adaptive resistance